This workshop will explore biological information through its dual nature: "digital" and "analog." These distinct modes of information processing in biological systems are deeply interconnected, collectively contributing to the regulation and functioning of living organisms. The "digital" aspect refers to genomic sequences —a linear, discrete coding system in DNA that operates via precise, rule-based codes (e.g., nucleotide sequences encoding proteins). This structure enables robust, error-corrected transmission of genetic information, allowing small, discrete units (genes) to be read, replicated, and passed on with high fidelity. Conversely, "analog" information arises from dynamic, continuous processes, particularly within signal-transduction pathways and cellular interactions. These pathways relay information in a graded manner, modulating responses to environmental stimuli, stress, or internal changes. The workshop seeks to advance understanding of biological information by emphasizing its dual nature and fostering synergy between theoretical and experimental perspectives.
Key questions include:
- How do theoretical models capture the interaction between digital genomic information and analog signal transduction pathways?
- Can a unified framework be developed to account for both types of information processing?
- How do findings in gene regulation, signaling networks, and epigenetics refine existing models of biological information?
- What roles do noise, stochasticity, and robustness play in these processes?
The workshop will highlight the potential of interdisciplinary collaborative research in addressing societal challenges, including AI development and applications, as well as public health, among other areas. These contributions aim to bridge the gap between research and real-world application, inspiring and motivating younger participants to pursue this complex and impactful career path.
Dates: 4-5 September 2025
Venue: Sozopol, Bulgaria, Hotel Villa List
Scientific Committee: Nevena Ilieva, Oreste Piro, Julyan Cartwright
Local Organizing Committee: Nevena Ilieva, Elena Lilkova
